Effect of Orexin-A on Cognitive Function of Patients with Epilepsy
- VernacularTitle:Orexin-A 对癫痫患者认知功能的影响
- Author:
Weixia YANG
1
;
Weiwen WU
;
Xiangzhi XIAO
;
Lin KAN
;
Jun ZHAO
;
Weifang YANG
Author Information
1. 复旦大学附属中山医院青浦分院神经内科
- Keywords:
Epilepsy;
Orexin-A;
Cognitive function
- From:
Chinese Journal of Clinical Medicine
2015;(4):516-518
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of serum orexin-A on cognitive impairment caused by epilepsy.Methods:The cogni-tive function of 80 epileptic patients and 40 healthy controls was evaluated by mini-mental state examination (MMSE),while the level of orexin-A in fasting venous blood sample was detected by enzyme linked immunosorbent assay (ELISA).Results:The incidence rate of cognitive impairment in epileptic group was higher than that in control group,and there was a significant difference (P <0.05).The level of orexin-A in epileptic patients with cognitive impairment was lower than that in epileptic pa-tients without cognitive impairment and healthy controls,and there was a significant difference (P <0.05).The level of orex-in-A in epileptic patients with severe cognitive impairment was lower than that in epileptic patients with mild or moderate cogni-tive impairment,and there were significant differences (P <0.05).Conclusions:The decreasing level of Orexin-A may be re-lated to cognitive impairment of epileptic patients.
