Effect of Tirofiban in Thrombolytic Therapy for Acute Myocardial Infarction
- VernacularTitle:替罗非班在急性心肌梗死溶栓治疗中的作用
- Author:
Jinfeng WANG
1
;
Ying WEI
;
Fang WANG
;
Cuiyan YANG
;
Guoyu WANG
Author Information
1. 中国人民解放军第二 O 八医院心血管内二科
- Keywords:
ST-segment elevation myocardial infarction;
Thrombolytic therapy;
Tirofiban
- From:
Chinese Journal of Clinical Medicine
2015;(4):491-493
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the efficacy and safety of tirofiban in thrombolytic therapy for acute ST-segment elevation myocardial infarction (STEMI).Methods:A total of 121 STEMI patients,who refused the emergency interventional therapy and accepted thrombolytic therapy,were chosen and randomly divided into two groups.The patients in the control group (n=54)were given routine thrombolytic therapy such as urokinase 22 000 U/kg and etc.The patients in the treatment group (n=67)were given tirofiban on the basis of routine thrombolytic therapy,and individual dose of tirofiban was adjusted according to CRUSADE bleeding risk score.The clinical effect and bleeding situations of patients in the two groups were observed.Results:Compared to that in the control group,the reperfusion rate improved significantly in the treatment group(95.5% vs.57.4%). There was no significant difference regarding reperfusion arrhythmia (76.6% vs.70.9%)and bleeding (16.4% vs.1 1 .1 %) between the two groups.Conclusions:Tirofiban can significantly improve the reperfusion rate of infarct blood vessels of STEMI patients in thrombolytic therapy,without increasing the risk of bleeding.It indicates that tirofiban is safe and efficacious in thrombolytic therapy for STEMI.
