Expression of MicroRNA-148b in Hepatocellular Carcinoma Tissue and Its Clinical Significance
- VernacularTitle:microRNA-148b 在肝细胞癌组织中的表达及其临床意义
- Author:
Yu-qing AO H
1
;
Xuwei IANG J
;
Yuzhen XU
Author Information
1. 上海市宝山区中西医结合医院普外科
- Keywords:
Hepatocellular carcinoma;
microRNA-148b;
Overall survival;
Prognosis
- From:
Chinese Journal of Clinical Medicine
2015;(4):471-474
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the expression of microRNA-148b(miR-148b)in human hepato-cellular carcinoma (HCC)and the prognosis of HCC.Methods:The specimens of HCC tissue and para-carcinoma tissue ac-quired by surgical resection during 2007 and 2010 were collected from frozen tissue specimen library of Shuguang Hospital Af-filiated to Shanghai University of Traditional Chinese Medicine.The expression of miR-148b in tissue specimen was detected by real-time quantitative polymerase chain reaction (RT-qPCR).The clinical significance of expression change of miR-148b was analyzed by considering the clinical pathological indicators and survival data.Results:The expression level of miR-148b in HCC was significantly lower than that in para-tumor tissues(P <0.01).Low expression of miR-148b was associated with HCC ma-lignant clinical pathological indicators such as vascular invasion and TNM stage.Kaplan-Meier survival curve analysis showed that the patients with low expression of miR-148b had poor overall survival rate.Conclusions:The expression of miR-148b de-creases in human HCC tissue.And it is associated with the poor clinical prognosis.
