Effects of Oxygen Therapy on Patients with Acute Myocardial Infarction during Emergency Percutaneous Coronary intervention
- VernacularTitle:吸氧在急性心肌梗死患者行经皮冠状动脉介入治疗中的作用
- Author:
Jun CHEN
1
;
Wanhong WANG
;
Ronglin ZHANG
;
Hao DING
;
Yong CHENG
Author Information
1. 江苏省南京鼓楼医院集团宿迁市人民医院心内科
- Keywords:
Oxygen therapy;
Acute myocardial infarction;
Combination drug therapy;
Percutaneous coronary interven-t io n
- From:
Chinese Journal of Clinical Medicine
2015;(3):322-326
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of oxygen therapy on patients with acute myocardial infarction (AMI) and without hypoxia ,who were treated with emergency percutaneous coronary intervention (PCI) .Methods:This study was a sin‐gle‐center ,prospective and randomized controlled study .A total of 143 patients with AMI and without hypoxia ,who were un‐dergoing emergency PCI were divided into oxygen group and control group .The patients in oxygen group inhaled oxygen at a flow rate of 5 L/min via nasal catheter for 24 hours ,the patients in control group inhaled air .Before and after PCI ,the patients in each group received standardized drug treatment (including anti‐thrombotic and anti‐ischemic drugs ,statins and angiotensin‐converting enzyme inhibitors) in Coronary Care Unit (CCU) .The situation of AMI and PCI were observed in the two groups . The clinical data including hospitalization time ,Global Registry of Acute Coronary Events (GRACE) score ,levels of cardiac troponin I(CTnI) ,myocardial‐specific isoenzyme of creatine kinase (CK‐MB) and N‐terminal pro‐B‐type natriuretic peptide (NT‐ProBNP) ,as well as the occurrence rates of cardiac arrhythmias ,cardiogenic shock and death were recorded and ana‐lyzed .Results:There were significant differences (all P<0 .05) between oxygen group and control group in peak concentra‐tions of serum CTnI[33 .40 (22 .10 ,75 .43) ng/mL vs .23 .70 (14 .83 ,45 .45) ng/mL] ,CK‐MB [(252 .70 ± 132 .20)U /L vs .(189 .66 ± 97 .05) U /L] and NT‐ProBNP [810(535 ,1390) pg/mL vs .406(240 ,846)pg/mL] as well as arrhythmia oc‐currence (13 vs .9 cases) .Bute there was no difference in cardiogenic shock ,death and hospitalization time between the two groups(all P>0 .05) .Conclusions:Oxygen therapy may have no benefit and even cause potential myocardial injury for AMI pa‐tients without hypoxia in the process of emergency PCI treatment .
