Research progress of renin angiotensin system on hypertrophic scar
10.3760/cma.j.cnZHZXWKZZ-2018-0814-00346
- VernacularTitle:肾素-血管紧张素系统在增生性瘢痕中的研究进展
- Author:
Chuchen ZHUANG
1
;
Xiaofeng WANG
;
Wanyi ZHAO
;
Yanyan HU
;
Dingding ZHANG
;
Bin ZHENG
;
Caiyun LI
;
Weiqiang TAN
Author Information
1. 浙江大学医学院附属邵逸夫医院整形外科，杭州 310016；丽水市人民医院整形烧伤外科 323000
- Keywords:
Hypertrophic scar;
Renin angiotensin system;
Angiotensin converting enzyme;
Angiotensinogen Ⅱ
- From:
Chinese Journal of Plastic Surgery
2020;36(6):696-700
- CountryChina
- Language:Chinese
-
Abstract:
Hypertrophic scar is a pathological lesion during the repair of skin wound, involving fibroblast, extracellular matrix and cytokines. The prevention and treatment of hypertrophic scar has been a clinical problem, but its exact mechanism is still unclear. The renin angiotensin system (RAS) in the skin is proved to directly involve in wound healing and hypertrophic scar formation. After local RAS activating during wound repair, the expression of angiotensinogen Ⅱ (Ang Ⅱ) and angiotensin converting enzyme (ACE) have increased. They can lead to pathological scarring by stimulating the proliferation of fibroblasts in the skin, affecting collagen metabolism, promoting skin fibrosis and angiogenesis. This review will focus on the role of Ang Ⅱ and ACE in hypertrophic scar formation, which will help to further understand the mechanism of scar formation, and summarize the potential application of RAS antagonists in hypertrophic scar prevention and treatment, so as to provide a new direction for the prevention and treatment of hypertrophic scar.
