The research progress of DNA methylation in melanoma

VernacularTitle:黑色素瘤DNA甲基化基因研究进展
Author: Shudan ZHENG ¹ ; Yuanhua HUANG ; Shimeng CHENG ; Fazhi QI ; Liang JIN ; Tianyi LIU ; Shirong LI ; Ningwen ZHU
Author Information

1. 复旦大学附属华山医院皮肤科，上海　200040
Keywords: Melanoma; DNA methylation; Gene; Biomarker
From: Chinese Journal of Plastic Surgery 2020;36(6):701-706
CountryChina
Language:Chinese
Abstract: Melanoma is a highly invasive and lethal skin malignant tumor derived from melanocytes. It has the characteristics of high early metastasis and high mortality. In recent years, with the in-depth study of the pathogenesis of melanoma, it has been found that epigenetic modification, especially DNA methylation, is considered to be a universal intrinsic feature of melanoma development and evolution. This article reviews the research progress of abnormal DNA methylation genes in melanoma in detail, and summarizes the biomarker effect of DNA methylation genes, suggesting that the detection of abnormal DNA methylation genes in melanoma patients is hopeful as an early screening index and diagnostic marker for melanoma patients.