Plastic surgery in the era of genetics and precision medicine
10.3760/cma.j.cn114453-20200316-00155
- VernacularTitle:遗传学与精准医疗时代的整形外科
- Author:
Xiaoxi LIN
1
;
Hao GU
;
Ren CAI
Author Information
1. 上海交通大学医学院附属第九人民医院整复外科 200011
- Keywords:
Precision medicine;
Genetics;
Plastic surgery;
Vascular malformations;
Hemangioma
- From:
Chinese Journal of Plastic Surgery
2020;36(5):471-476
- CountryChina
- Language:Chinese
-
Abstract:
When plastic surgery meets the era of genetics and genetics-based precision medicine, how will we plastic surgeons face it ? As an example, this article systematically reviewed the identification of serum biomarkers, risk factors, specific genes such as GNAQ, RASA1, TEK and their influences on the diagnosis and treatment of vascular anomalies with the preliminary result found in genetics of hemangiomas and vascular malformations for precision medicine. In addition, a new disease classification system and a treatment breakthrough for complicated vascular malformation based on the innovative genetic evidence, the PIK3CA gene, were briefly summarized. With gene sequencing, bioinformatics and big data, in the hand of China’s huge medical research scale, genetics and precision medicine will provide an inexhaustible driving force for the sustainable development of plastic surgery in the future.
