The Effect of AMD3100 on the Efficacy of Sorafenib in the Treatment of Hepatocellular Carcinoma
- VernacularTitle:AMD3100对索拉非尼治疗肝细胞肝癌的疗效影响
- Author:
Lu LU
1
;
Wenwei ZHU
;
Jinhong CHEN
;
Huliang JIA
Author Information
1. 复旦大学附属华山医院普外科
- Keywords:
AMD3100;
Sorafenib;
Hepatocellular carcinoma
- From:
Chinese Journal of Clinical Medicine
2015;(2):140-142
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of AMD3100 ,an inhibitor of receptor of stromal cell derived factor 1‐α (SDF1‐α) ,combined with sorafenib on nude mice with hepatocellular carcinoma (HCC) .Methods:Nude mice models of HCC in situ was established and the mice were divided into control group ,sorafenib group and sorafenib combined with AMD3100 group , with six mice in each group .In sorafenib group ,sorafenib 30 mg/(kg · d) was given by garage .In sorafenib combined with AMD3100 group ,AMD3100 2 .5 mg/(kg · d) was administrated by intraperitoneal injection based on the method of sorafenib group .In the control group ,0 .9% sodium chloride solution was given by garage . The intrahepatic invasion , the tumor volume ,the situation of pulmonary metastasis and the survival time of nude mice ,were compared among the three groups . Results:When sorafenib was combined with AMD3100 ,the intrahepatic invasion and metastasis of HCC caused by sorafenib could be significantly inhibited .Thus the tumor volume was decreased and the pulmonary metastasis could be reduced .The survival time was prolonged .Conclusions:AMD3100 ,a SDF1‐α receptor inhibitor ,can enhance the efficacy of sorafenib .
