Predictive Value of Polymorphisms in the TNFAIP8 Gene Family for Clinical Outcomes of Cervical Cancer
- VernacularTitle:TNFAIP8家族基因单核苷酸多态性位点在宫颈癌预后评估中的作用
- Author:
Tingyan SHI
1
;
Jing HE
;
Mengyun WANG
Author Information
1. 复旦大学附属中山医院妇产科
- Keywords:
Cervical cancer;
TNFAIP8 gene family;
Polymorphism;
Prognosis
- From:
Chinese Journal of Clinical Medicine
2015;(2):126-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the predictive value of polymorphisms in the tumor necrosis factor‐α‐induced protein 8 (TNFalP8) gene family in the prognosis of cervical cancer .Methods:A total of 144 cervical cancer patients who had been followed up for at least two years were recruited . Three polymorphism sites TNFalP8‐rs11064 , TNFalP8‐rs3813308 and TNFalP8L1‐rs1060555 in the TNFalP8 gene family were genotyped by the Taqman assay .The associations of polymorphisms in the TNFalP8 gene family with prognosis of cervical cancer were analyzed . Results:Compared with CG/CC genotypes ,tumor recurrence in TNFalP8L1‐rs1060555 GG genotype carriers increased (adjusted HR=3 .25 ,95% CI:1 .06‐9 .95) .Combined analysis for the three polymorphisms indicated that compared with 0‐1 risk genotype carriers ,tumor recurrence in 2‐3 risk genotype carriers increased (adjusted HR = 2 .55 ,95% CI:1 .02‐6 .36) . Conclusions:Polymorphisms in TNFalP8 gene family may be predictive biomarkers for prognosis of cervical cancer .
