Effects of Sevoflurane and Nitrous Oxide Anesthesia on Spatial Recognition in Aged Rats
- VernacularTitle:七氟醚及笑气麻醉对老年大鼠空间认知能力的影响
- Author:
Guoxia ZHOU
1
;
Lichao PENG
Author Information
1. 复旦大学上海市第五人民医院麻醉科
- Keywords:
Aged rats;
Learning and memory;
Sevoflurane;
Nitrous oxide;
Morris water maze
- From:
Chinese Journal of Clinical Medicine
2015;(1):73-75
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the effects of sevoflurane and nitrous oxide anesthesia on spatial recognition in young and aged rats .Methods :Young(3 months ,n=12) and aged(18 months ,n=12) rats were divided randomly into anesthesia group (sevoflurane at 1 minimum alveolar concentration ,70% nitrous oxide ,30% oxygen ,for 4 h ,n=6) and control group(30%oxygen ,for 4 h ,n=6) .After 48 h ,training on spatial learning and memory (probe trial) were done in the Morris water maze for 6 days .Spatial exploration test was conducted at 24 h after training .Result:Sevoflurane and nitrous oxide exposure induced a significant deficit in spatial recognition in aged rats ,but not young rats .Conclusions :A significant deficit in spatial recognition in aged rats can be induced by sevoflurane and nitrous oxide exposure ,which may due to that the aged brain is more susceptible to anesthetic‐mediated changes .
