Value of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in the Differential Diagnosis of Benign and Malignant Pleural Effusion
- VernacularTitle:基质金属蛋白酶和金属蛋白酶组织抑制剂对良恶性胸腔积液的鉴别诊断价值
- Author:
Ling QIAN
1
;
Zhijun JIE
;
Juan XIE
;
Chuan SHAO
;
Fen ZHU
;
Zilong LIU
;
Shanqun LI
;
Jindong SHI
Author Information
1. 复旦大学附属上海市第五人民医院呼吸科
- Keywords:
Pleural effusion;
Matrix metalloproteinases;
Tissue inhibitors of metalloproteinases;
Differential diagnosis
- From:
Chinese Journal of Clinical Medicine
2015;(1):54-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the value of matrix metalloproteinase (MMP)‐7 ,MMP‐10 and tissue inhibitor of matrix metalloproteinase(TIMP)‐1 ,TIMP‐2 in the differential diagnosis of benign and malignant pleural effusion .Methods :The concentrations of MMP‐7 ,MMP‐10 ,TIMP‐1 and TIMP‐2 in 38 cases of malignant pleural effusion and 50 cases of benign pleural effusion were detected by enzyme‐linked immunosorbent assay(ELISA) .Results:(1)The concentrations of MMP‐7 , MMP‐10 and the MMPs/TIMPs ratios were higher in malignant pleural effusion than those in benign pleural effusion (P<0 .01) .There was no significant difference in the concentrations of TIMP‐1 ,TIMP‐2 between benign pleural effusion and malignant pleural effusion(P> 0 .05) .(2)While single‐index were used in the differential diagnosis of benign and malignant pleural effusion ,MMP‐7 ,MMP10 and the MMPs/TIMPs ratios showed good diagnostic efficiency .The demarcation points of MMP‐7 ,MMP‐10 ,MMP‐7/TIMP‐1 ratio ,MMP‐10/TIMP‐1 ratio ,MMP‐7/TIMP‐2 ratio and MMP‐10/TIMP‐2 ratio were 328 .17 ng/mL ,246 .13 ng/mL ,0 .635 ,0 .478 ,0 .564 ,0 .438 , respectively . The corresponding sensitivities of them were 81 .6% ,97 .4% ,81 .6% ,89 .5% ,78 .9% ,74 .2% ,respectively .The corresponding specificities of them were 66 .0% ,60 .0% , 80 .0% ,70 .0% ,68 .0% , 72 .0% , respectively . Conclusions :M M P7 ,M M P‐10 are closely related to the development of malignant pleural effusion .The imbalance of MMPs/TIMPs ratio plays a great role in the pathogenesis of malignant pleural effusion .To detect MMP7 ,MMP‐10 and MMPs/TIMPs ratio of pleural effusion is conducive to the differential diagnosis of benign and malignant pleural effusion .
