Correlation of Transforming Growth Factor β1 with Microvessel Density and Prognosis in Breast Cancer
- VernacularTitle:转化生长因子β1与乳腺癌微血管密度及预后的相关性
- Author:
Ye SHEN
1
;
Meiyu XU
;
Youhua SHENG
Author Information
1. 上海市奉贤区中心医院普外科
- Keywords:
Breast cancer;
Transforming growth factor β1;
Microvessel density;
Prognosis
- From:
Chinese Journal of Clinical Medicine
2015;(1):41-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation of the expression of transforming growth factor β1(TGF‐β1) in breast cancer tissues with the microvessel density (MVD) in breast cancer tissues ,as well as the prognosis of breast cancer patients . Methods :The expression of TGF‐β1 in the tissues of breast cancer (n=62) and breast fibroadenoma(n=30) were detected with immunohistochemical staining ,and the MVD was counted .The correlation of the two factors with the pathological features were analyzed .The influence of TGF‐β1 on recurrence ,metastasis and survival rate were analyzed in combination with the follow‐up data .Results:The positive expression rate of TGF‐β1 protein and the count of MVD in breast cancer tissues were significantly higher than those in breast fibroadenoma tissues (P< 0 .05) .The positive expression rate of TGF‐β1 protein in breast cancer tissues increased as the increase of tumor diameter ,clinical stage ,lymph node metastasis(P<0 .05) ,and the count of MVD was correlated with clinical stage and lymph node metastasis (P<0 .05) .The expression level of TGF‐β1 protein was positively correlated with the count of MVD in breast cancer tissues (r=0 .705 ,P<0 .05) .The 5‐year survival rate in patients with positive expression of TGF‐β1 was significantly lower than those with negative expression of TGF‐β1 ( P< 0 .05 ) . Conclusions :TGF‐β1 is overexpressed in breast cancer tissues and is positively correlated with the count of MVD .TGF‐β1 plays an important role during the process of occurrence and development in breast cancer ,and it is a potential biological target for anti‐angiogenesis therapy in breast cancer .
