Research on Correlation between Serum Lipid Levels and Diabetic Nephropathy in Patients with Type 2 Diabe-tes Mellitus
- VernacularTitle:2型糖尿病患者的血脂指标与糖尿病肾病的相关性研究
- Author:
Ya′nan SHI
1
;
Yu SHI
;
Xiaofeng LI
;
Dongqin WEI
;
Chunsun FAN
;
Yawei ZHANG
Author Information
1. 江苏省启东市人民医院内分泌科
- Keywords:
Dyslipidemia;
Type 2 diabetic mellitus;
Diabetic nephropathy;
Case-control study
- From:
Chinese Journal of Clinical Medicine
2014;(6):677-679
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation between serum lipid levels and diabetic nephropathy in patients with type 2 di-abetic mellitus.Methods:A total of 240 patients with type 2 diabetic mellitus from Jun 2011 to Jul 2013 were enrolled.There were 100 patients with diabetic nephropathy and 140 patients without any complication.Gender,age,duration of diabetes, baseline fasting glucose,glycosylated hemoglobin and serum lipid were compared between the two groups.The odds ratio(OR) and 95% confidence interval(CI)of correlation between these factors and diabetic nephropathy were calculated and analyzed with Logistic regression model.Results:The differences of age,duration of diabetes,systolic pressure between the two groups were statistically significant(P <0.01).Adjusted Logistic regression model showed that age> 70(OR= 2.92,95% CI:1.31-6.51),duration of diabetes>10 years(OR=3.33,95%CI:1.79-6.16),diastolic pressure>90 mmHg(OR=2.23,95%CI:1.06-4.69),and low density lipoprotein>3.64 mmol/L(OR=2.85,95%CI:1.16-7.03)were independent risk factors for type 2 Dia-betic Mellitus complicated by diabetic nephropathy(P <0.01 and 0.05).Conclusions:Low density lipoprotein has the potential to be a predictive,prophylactic and therapeutic target for diabetic nephropathy.
