Influence of Esmolol on the Dosing of Remifentanil in Total Intravenous Anesthesia
- VernacularTitle:艾司洛尔对全凭静脉麻醉中瑞芬太尼用量的影响
- Author:
Yun REN
1
;
Fang FANG
;
Jing CANG
;
Qingxiu WANG
Author Information
1. 复旦大学附属中山医院麻醉科
- Keywords:
Esmolol;
Remifentanil;
Total intravenous anesthesia;
Target-controlled infusion
- From:
Chinese Journal of Clinical Medicine
2014;(6):674-676
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the influence of esmolol on the dosing of remifentanil in total intravenous anesthesia(TIVA). Methods:A total of 40 female patients scheduled for thyroid surgery were randomly divided into 2 groups,with 20 patients in each group.The patients in the study group received a loading dose of esmolol through continuous intravenous infusion after tra-cheal intubation.The infusion was stopped after extubation.The control group received the same volume of 0.9% sodium Chlo-ride.The target concentration of propofol was adjusted by bispectral index,and the target concentration of remifentanil was ad-justed by heart rate and mean artery pressure.Intraoperative heart rate,mean artery pressure and bispectral index,as well as postoperative pain scores,were recorded.Results:There was no significant difference in heart rate,mean artery pressure and bispectral index between the two groups(P >0.05).The dosage of remifentanil in the study group was lower than that in the control group(P <0.01).The pain score was higher in the study group at 5 min after entering postanesthetic care unit(PACU) than that in the control group(P <0.05).There was no statistical significance in pain scores at 30 min after entering PACU and at 24 h after surgery (P <0.05)between the two groups.Conclusions:Continuous low dosage infusion of esmolol could signifi-cantly decrease the consumption of remifentanil in TIVA.
