A Preliminary Study on the Intraoperative Myocardial Protection Effect of Dexmedetomidine in Patients with Hypertension
- VernacularTitle:右旋美托咪定对高血压患者手术期心肌保护作用的初步研究
- Author:
Nu ZHANG
1
;
Wei XU
;
Li LIU
Author Information
1. 复旦大学附属金山医院麻醉科
- Keywords:
Dexmedetomidine;
Hypertension;
Myocardial protection
- From:
Chinese Journal of Clinical Medicine
2014;(6):671-673
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore whether there was intraoperative myocardial protection effect of dexmedetomidine in patients with hypertension.Methods:A total of 60 patients with hypertension undergoing elective abdominal surgery,who were classi-fied as Ⅰ-Ⅱ according to American Society of Anesthesiologists(ASA)criteria and aged 22-60 years old with body mass index (BMI)19-26 kg/m2 ,were randomly divided into dexmedetomidine group and control group,with 30 cases in each group.Pa-tients in dexmedetomidine group were given a loading dose of dexmedetomidine 0.5 μg/kg(10 min before the operation)which was followed by a continuous infusion of 0.2 μg/(kg·h)till 30 minutes before the end of operation.Patients in the control group were intravenously pumped 0.9% sodium chloride solution.The serum concentration of cardiac troponin I (cTnI),inter-leukin 6(IL-6)and tumor necrosis factor-α(TNF-α)were measured before anesthesia induction and at 6h and 24h after opera-tion.Results:There were significant differences in cTnI,IL-6 and TNF-αin control group at 6 h and 24 h after operation com-pared with those before anesthesia induction(P <0.05).There were significant differences in IL-6 at 24 h after operation and TNF-αat 6 h and 24 h after operation in dexmedetomidine group compared with those before anesthesia induction(P <0.05). The concentration of cTnI,IL-6 and TNF-αin dexmedetomidine group were significantly lower than those in the control group at 6 h and 24 h after operation(P <0.05).Conclusions:There was certain intraoperative myocardial protection effect of dexme-detomidine in patients with hypertension.
