Analysis of SPECT/CT Fusion Imaging of Bone Metastases in Patients with Lung Cancer
- VernacularTitle:肺癌骨转移 SPECT／CT 融合图像的影像学特点分析
- Author:
Yiqiu ZHANG
1
;
Hongcheng SHI
;
Beilei LI
;
Yan XIU
;
Yushen GU
;
Shuguang CHEN
;
Liang CAI
Author Information
1. 复旦大学附属中山医院核医学科
- Keywords:
Lung cancer;
Bone metastasis;
SPECT/CT
- From:
Chinese Journal of Clinical Medicine
2014;(6):633-635,639
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the 99 Tcm-methylene diphosphonate single photon emission computed tomography/spiral computed tomography (SPECT/CT)fusion imaging of bone metastases in patients with lung cancer and to evaluate the value of SPECT/CT in differentiating metastases from benign bone lesions.Methods:A total of 113 patients with bone metastases from lung cancer confirmed by pathology underwent bone scintigraphy and SPECT/CT imaging.Metastatic bone sites,quantity,up-take of radiotracer,and CT manifestations of each lesion were analyzed via bone scintigraphy imaging and SPECT/CT fusion imaging.Results:A total of 482 lesions from 113 patients were analyzed in this study.Among them,429 lesions were metasta-ses.Metastatic sites included spine(50.6%),thorax (29.1% ),pelvis (17.0%),extremities (2.1%),and skull(2.1%).CT manifestations were osteoblastic (41.0%),osteolytic (50.3%),mixed (4.0%),and normal (4.7%).Among these lesions, the proportion of hot spots displayed on SPECT/CT pictures was 90.7%(389/429),and the proportion of lesions with normal uptake of radiotracer was 9.3%(40/429).There were 53 benign lesions in 23 patients with bone metastasis.Conclusions:The most frequent metastatic sites in patients with lung cancer are spine and thorax.Bone metastasis from squamous carcinoma is more com-mon than from other types of lung cancer.The common CT manifestations are osteoblastic.The sensitivity and specificity of SPECT/CT fusion images for the diagnosis of bone metastatic lesions of lung cancer are high.
