Observation on Efficacy of Calcipotriol Betamethasone Ointment Combined with Narrow-Band Ultraviolet B in the Treatment of Psoriasis Vulgaris in Stable Phase
- VernacularTitle:钙泊三醇倍他米松乳膏联合窄谱中波紫外线治疗稳定期寻常型银屑病的疗效分析
- Author:
Qiang WANG
1
;
Liqiao CHI
Author Information
1. 复旦大学附属中山医院青浦分院皮肤科
- Keywords:
Psoriasis vulgaris;
Calcipotriol betamethasone;
Calcipotriol;
Mometasone furoate;
Narrow-band ultravi-olet B
- From:
Chinese Journal of Clinical Medicine
2014;(5):586-588
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the efficacy and safety of calcipotriol betamethasone ointment,calcipotriol ointment and mo-metasone furoate cream respectively combined with narrow-band ultraviolet B(NB-UVB)in the treatment of psoriasis vulgaris. Methods:Ninety patients of psoriasis vulgaris were randomly divided into three groups,with 30 cases in each group.Thirty pa-tients in the treatment group were treated with calcipotriol betamethasone ointment;thirty patients in the control group A were treated with calcipotriol ointment,and thirty patients in the control group B were treated with mometasone furoate cream.All the three groups were given specific medications once daily by applying to the skin lesions.NB-UVB treatment was applied three times a week during the period of medication treatment.The duration of treatment was four weeks.Efficacy was observed once a week during the treatment.Results:At week 2 of the treatment,the effective rate in the treatment group was 36.67%, which was higher than that in the control group A(13.33%)and control group B (13.33%).The difference was significant (P <0.05)Observation at week 4 showed that the efficacy of the treatment group was better than that of the two control groups.The difference was statistically significant (P < 0.05).Adverse events of the treatment group mainly included skin burning sensation and erythema which could be tolerated.Conclusions:Calcipotriol betamethasone ointment,calcipotriol oint-ment and mometasone furoate cream respectively combined with NB-UVB were efficacious and safe in the treatment of psoriasis vulgaris.However,calcipotriol betamethasone ointment takes faster and better effect,and less adverse reaticons.
