Influence of Patient-Controlled Intravenous Analgesia with Morphine on Early Postoperative Cognitive Func-tion in the Elderly Patients Undergoing Abdominal Surgery with Total Intravenous Anesthesia
- VernacularTitle:吗啡静脉自控镇痛对老年患者静脉麻醉腹部手术后早期认知功能的影响
- Author:
Fang WANG
1
;
Yizhen YAO
;
Jiequn DAI
;
Lichao PENG
Author Information
1. 复旦大学附属上海市第五人民医院麻醉科
- Keywords:
Patient-controlled intravenous analgesia;
Postoperative cognitive dysfunction;
Elderly patients
- From:
Chinese Journal of Clinical Medicine
2014;(5):561-563
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the influence of patient-controlled intravenous analgesia(PCIA)with morphine on early post-operative cognitive function in the elderly patients undergoing abdominal surgery with target control infusion(TCI)/total intra-venous anesthesia(TIVA).Methods:A total of 120 patients matched with the inclusion criteria were randomly divided into PCIA group with morphine(n=60)and control group(n=60).All the patients underwent abdominal operation with TCI/TI-VA.Pain intensity at 24 h and 48 h after the operation were evaluated by visual analogue scale(VAS).Mini-mental state examination(MMSE)scores were recorded at 24 h before the operation and 24 h,48 h,72 h after the operation,in order to as-sess cognitive function and incidence of POCD.Results:Scores of VAS in PCIA group were significantly lower than those in control group at 24 h and 48 h after the operation(P <0.01).The incidence of postoperative cognitive dysfunction(POCD)at 72 h after the operation in PCIA group was lower than that in the control group (P <0.05),and recovery of postoperative cog-nitive function in PCIA group was better than that in the control group(P <0.05).Conclusions:PCIA with morphine could re-duce the incidence of POCD in the elderly patients undergoing abdominal surgery and improve postoperative cognitive function.
