Serum and Sputum Levels of Surfactant Protein D in Patients with Chronic Obstructive Pulmonary Disease and the Clinical Significance
- VernacularTitle:慢性阻塞性肺疾病患者血清和痰液中表面活性蛋白D的水平及临床意义
- Author:
Yanhong DUAN
1
;
Chunling DU
;
Jian XIAO
;
Feng ZHOU
;
Donghui XU
;
Chaomin WU
;
Lei ZHOU
Author Information
1. 复旦大学附属中山医院青浦分院呼吸内科
- Keywords:
Chronic obstructive pulmonary disease;
Acute exacerbation;
Surfactant protein D
- From:
Chinese Journal of Clinical Medicine
2014;(5):537-539
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the levels and clinical significance of serum and sputum surfactant protein D (SP-D)in pa-tients with chronic obstructive pulmonary disease (AECOPD).Methods:Thirty-four patients with AECOPD (Group A),37 patients with stable COPD (Group B),30 healthy people with smoking history (Group C),and 30 helthy people without smok-ing history (Group D)were enrolled.SP-D levels in the serum and sputum of the four groups were detected and compared. Moreover,the correlation between serum SP-D level and sputum SP-D level in patients with AECOPD was analyzed.Results:The serum SP-D levels in Group A,Group B,Group C and Group D were (165.09±16.72)ng/mL,(126.48± 15.64)ng/mL, (72.85±8.62)ng/mL and(54.70±7.29)ng/mL,respectively.The sputum SP-D levels in Group A,Group B,Group C and Group D were (109.03 ± 18.95)ng/mL,(133.28± 16.36)ng/mL,(260.04±47.91)ng/mL and(665.89± 117.49)ng/mL. There were significant differences in the levels of serum and sputum SP-D among the four groups(P <0.05).Serum SP-D level and sputum SP-D level in patients with AECOPD were negatively correlated (r=-0.698,P <0.05).Conclusions:The detec-tion of SP-D levels in serum and sputum contributes to the clinical assessment of AECOPD.There is a negative correlation be-tween serum SP-D level and sputum SP-D level in AECOPD patients.
