Detection and Significance of Serum Th17 Cell Related Cytokines in Patients with Bronchial Asthma
- VernacularTitle:支气管哮喘患者血清中 Th17细胞相关细胞因子的检测及意义
- Author:
Xia AN
1
;
Ling YE
;
Ying GONG
;
Dong YANG
;
Li LI
;
Meiling IN J
Author Information
1. 复旦大学附属中山医院呼吸科
- Keywords:
Transforming growth factor-β1;
Interleukin-17;
Interleukin-23;
Asthma;
Airway remodeling
- From:
Chinese Journal of Clinical Medicine
2014;(5):513-516
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the serum levels of transforming growth factor-β1 (TGF-β1),interleukin-17 (IL-17),inter-leukin-23 (IL-23)in patients with bronchial asthma at different degrees of airway obstruction after standardized treatment,in order to explore the significance of TGF-β1,IL-17,IL-23 in airway remodeling in patients with asthma.Methods:Ninety-one asthma patients,who underwent standardized treatment for at least three months,were recruited by applying control study.By using FEV1%pred as grouping criterion,the 91 patients with asthma were divided into the mild asthma group (FEV1%pred≥80%),the moderate asthma group (60 %< FEV1 %< 80%)and the severe asthma group (FEV1 %≤60%).In addition, 27 healthy people were selected as control group.The serum levels of TGF-β1,IL-17,and IL-23 in each group were monitored and compared with each other.Results:1.Compared with that in the control group,the serum levels of TGF-β1 in asthma group were higher,while the levels of IL-17 were lower.There was no significant difference in serum IL-23 level between the two groups.2.Comparison were done among the asthma groups.There were significant differences in serum levels of TGF-β1 and IL-17 between mild asthma group and moderate-to-severe asthma group (P < 0.05 ),while there were no significant differences between moderate group and severe group.3.Serum IL-17 level was correlated negatively with TGF-β1 level. FEV1%pred was correlated negatively with serum TGF-β1 level and positively with serum IL-17 level,while it had no correla-tion with serum IL-23 level.Conclusions:In patients with asthma,the serum TGF-β1 level is negatively correlated with FEV1%pred,which indicates that TGF-β1 is an important index for airway remodeling.The serum levels of IL-17 in patients with asthma is lower than those in healthy people.Furthermore,the decrease of serum IL-17 level is more significant while the obstruction is worse.The probable answer is that persistent airway inflammation inhibits secretion and expression of IL-17,so that the expression of IL-17 declines in phase with severe impairment of pulmonary function and severe airway remodeling.
