Long-term effect of botulinum toxin type A injection on hypertrophic acne scar
10.3760/cma.j.issn.1009-4598.2016.06.009
- VernacularTitle:A型肉毒毒素治疗痤疮性瘢痕的远期随访观察
- Author:
Suzhuang HONG
1
;
Jingjing ZHANG
;
Fan HONG
Author Information
1. 361004,厦门大学附属中山医院整形外科
- Keywords:
Botulinum toxin type A;
Injections;
Acne vulgaris;
Cicatrix;
Treatment outcome
- From:
Chinese Journal of Plastic Surgery
2016;32(6):432-437
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate both the short-and long-term effect of botulinum toxin type A (BTXA) injection on hypertrophic ache scar.Methods A total of 26 patients with acne scar received BTXA injection of within 100 units.The effect was evaluated using the ECCA grading scale before treatment and during clinic re-visit,which based on history of acne scar and number of scar area.The short-and long-term effect was recorded.The average follow-up period was 39.23 months.All results were evaluated by SPSS 21.0.ANOVA was used to evaluate average value and standard deviation of ECCA grading scale.Kaplan-Meier survival curve was used to evaluate relapse-free period,and Pearson test was used to detect relevant factors of relapse-free period.Results The BTXA injection showed significant positive long-term effect on inflammatory or hypertrophic acne scar.The average ECCA grading scale was 103.460 ±36.872 before treatment,79.620 ±37.146 at 6 months after treatment,63.160 ±24.049 at 12 months after treatment,47.500 ±4.629 at 18 months after treatment,and 50.000 ± 0.000 at 24 months after treatment,showing significant differences between any of two groups (P ＜ 0.01).Average relapsefree period was 28.354 ± 1.775 months.Relapse-free period was related to ECCA grading scale pre treatment and injection times (P ＜ 0.01);meanwhile,dose of BTXA and length of disease all had statistical significance (P ＜ 0.05);however,age and gender had no statistical significance (P ＞ 0.05).Conclusions The BTXA injection can relieve inflammation and improve scar texture in patients with hypertrophic acne scar in both the short-and long-term follow-up.
