Effect of Progesterone Treatment during Early Pregnancy on Natural Pregnancy Outcome in Patients with En-dometriosis
- VernacularTitle:孕早期孕酮治疗对子宫内膜异位症患者自然妊娠结局的影响
- Author:
Qiaoyan LIN
1
;
Danmei LIN
;
Yuan LIN
;
Jinbang XU
Author Information
1. 福建医科大学教学医院福建省妇幼保健院妇科
- Keywords:
Endometriosis;
Progesterone;
Natural pregnancy outcome
- From:
Chinese Journal of Clinical Medicine
2014;(3):282-284
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of progesterone treatment during early pregnancy on natural pregnancy outcome in patients with endometriosis .Methods :A total of 120 postoperative endometriosis patients with single natural intrauterine preg-nancy from January 2008 to January 2013 were enrolled and randomly divided into Group A and Group B ,with 60 cases in each group .Meanwhile ,100 cases of normal single intrauterine pregnancy in the same period were enrolled as control group (Group C) .Serum progesterone levels were detected regularly in the three groups .Those who had lower progesterone levels (lower than 15 ng/mL) in Group A were treated with progesterone and the dose of progesterone was adjusted according to serum pro-gesterone level .Pregnancy outcomes of patients in the three groups were compared .Results:At 5~5+6 gestational weeks ,the progesterone levels of Group A and Group B were significantly lower than that of Group C [(14 .3 ± 5 .2)ng/mL、(15 .1 ± 4 .9) ng/mL vs .(19 .3 ± 3 .8)ng/mL] ,P<0 .05 .After progesterone treatment ,the serum progesterone level was significantly in-creased in Group A .At 6~6+6 gestational weeks ,no statistically significant difference in serum progesterone level was found between Group A and Group C (P>0 .05);serum progesterone level in Group B was signficantly lower than that in Group C (P<0 .05) .At 10~10+6 gestational weeks ,no statistically significant difference in serum progesterone level was found among the three groups (P> 0 .05) .The incidence of early embryonic diapause in Group B (11 .7% )was significantly higher than those in Group A (3 .3% ) and Group C (5 .0% ) ,P<0 .05 .No statistically significant differences in the incidences of abortion , stillbirth ,premature delivery and fetal malformation were found among the three groups .Conclusions :Detection of serum pro-gesterone level and replenishing of progesterone timely in the early natural pregnancy women with endometriosis can reduce em-bryonic diapauses .The optimal time to replenish progesterone may be at 5~10 gestational weeks .
