Efficacy of Non-Bioartificial Liver in the Treatment of Children with Acute Liver Failure
- VernacularTitle:非生物型人工肝治疗儿童急性肝衰竭的疗效分析
- Author:
Jinhao TAO
1
;
Weiming CHEN
;
Jing HU
;
Jun HE
;
Jian MA
;
Zhujin LU
;
Guoping LU
Author Information
1. 复旦大学附属儿科医院重症医学科
- Keywords:
Acute liver failure;
Non-bioartificial liver;
Children
- From:
Chinese Journal of Clinical Medicine
2014;(3):273-275
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical effectiveness of non-bioartificial liver in the treatment of children with acute liver failure(ALF) .Methods :The clinical datum of 47 children with ALF from Aug 2008 to Jul 2013 treated in Children's Hos-pital ,Fudan University were retrospectively analyzed .Among them ,17 children were treated with only conventional compre-hensive medical treatment (control group) ,and the other 30 children were treated with non-bioartificial liver in addition to con-ventional comprehensive medical treatment (study group) .The distributing characteristics of age and etiological factors were analyzed .The main biochemical parameters and coagulation function parameters before and after treatment were compared in the study group and mortality rate was compared between the two groups .Results:In 47 children with ALF ,the cases ≤1 year old ,1-3 years old and ≥3 years old were 23 ,10 and 14 ,respectively .The percentage of unknown reasons in children with ALF was 34 .0% .Compared with before treatment ,serum total bilirubin(TBIL) ,alanine aminotransferase(ALT) and aspartate ami-notransferase(AST) decreased after treatment in the study group (P< 0 .05) ,and international normalized ratio (INR) ,pro-thrombin time activity(PTA) ,and albumin(ALB) significantly increased(P<0 .05) .The mortality rate in the study group was lower than that in the control group ,but the difference was not statistically significant .Conclusions :Non-bioartificial liver is effective for the treatment of children with ALF ,and can improve biochemical parameters ,coagulation function and prognosis .
