Expression and Clinical Significance of UHRF1 in Hepatocellular Carcinoma
- VernacularTitle:U HRF1在肝细胞肝癌中的表达及意义
- Author:
Guoming SHI
1
;
Jiabin CAI
;
Jingxian YU
;
Aiwu KE
;
Zhaoru DONG
;
Chi ZHANG
;
Pengfei ZHANG
;
Shuangjian QIU
;
Huichuan SUN
;
Jian ZHOU
;
Jia FAN
Author Information
1. 复旦大学附属中山医院肝外科
- Keywords:
Hepatocellular carcinoma;
Ubiquitin-like;
containing PHD and RING finger domains 1;
Clinicopathological characteristics;
Epigenetics
- From:
Chinese Journal of Clinical Medicine
2014;(3):242-244
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of UHRF1 and its relationships with the clinicopathological characteristics in hepatocellular carcinoma(HCC) .Methods :The expression of UHRF1 was analyzed in 556 cases of tumor tissues and peritumor tissues of HCC by immunohistochemistry .The relationships of UHRF1 with the clinicopathological characteristics of HCC were assayed .Results:Immunohistochemistry showed that positive staining of UHRF1 located in the nucleus of HCC cells .The ex-pression levels of UHRF1 protein were higher in tumor tissues than in peritumor tissues .HCC patients with positive expression of UHRF1 protein accounted for 59% of the whole cohort .The expression of UHRF1 protein was significantly correlated with the size of tumor ( P<0 .01) ,differentiation (P<0 .05) and microvessel invasion(P<0 .01) .Conclusions :The overexpression of UHRF1 is correlated with the malignant phenotypes of HCC and probably implicated in the invasion and metastasis of HCC .
