Role of Mitochondria in Ferroptosis and Its Relationship to Tumors
10.3779/j.issn.1009-3419.2024.102.34
- VernacularTitle:线粒体在铁死亡中的作用及其与肿瘤的关系
- Author:
ZHANG ZHANRUI
1
;
LIU HONGYU
;
CHEN JUN
Author Information
1. 832003 石河子,石河子大学医学院第一附属医院胸外科
- Keywords:
Ferroptosis;
Mitochondria;
GPX4;
Lipid peroxidation
- From:
Chinese Journal of Lung Cancer
2024;27(10):785-791
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a recently discovered form of cell death that is distinct from apoptosis,characterized pri-marily by the accumulation of intracellular iron and increased levels of lipid peroxidation.Resistance of tumor cells to ferrop-tosis can promote tumorigenesis and tumor progression.Various compounds can influence tumor development by triggering ferroptosis.Ferroptosis involves complex regulatory mechanisms,with mitochondria serving as both an iron storage and meta-bolic center,playing a crucial regulatory role in ferroptosis.This review discusses ferroptosis and its three stages and the role of ferroptosis in tumorigenesis,progression,and treatment,as well as the regulatory mechanisms of mitochondria in ferroptosis.
