Advances of Fundamental Research on Traditional Chinese Medicine in Regulation of Tumor-associated Macrophages for the Prevention and Treatment of Lung Cancer Metastasis
10.3779/j.issn.1009-3419.2024.106.14
- VernacularTitle:中医药调控肿瘤相关巨噬细胞防治肺癌转移的基础研究进展
- Author:
LIU SHIHUI
1
,
2
;
LI JIAXUAN
;
QUE ZUJUN
;
YU PAN
;
TIAN JIANHUI
Author Information
1. 200071 上海,上海中医药大学附属市中医医院肿瘤临床医学中心
2. 200071 上海,上海中医药大学附属市中医医院肿瘤研究所
- Keywords:
Tumor-associated macrophages;
Polarization;
Lung neoplasms;
Metastasis;
Traditional Chinese medi-cine
- From:
Chinese Journal of Lung Cancer
2024;27(7):541-549
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is the leading cause of cancer-related deaths worldwide,with metastasis being the primary cause of mortality in lung cancer patients,and its prevention and control efficacy remain limited.In recent years,immunothera-py has emerged as a promising direction for overcoming the bottleneck of metastasis.Macrophages,as essential components of innate immunity,participate in the entire process of tumor initiation and progression.Tumor-associated macrophages(TAMs)represent the most abundant immune population in the tumor microenvironment(TME),displaying both anti-tumor M1-like and pro-tumor M2-like phenotypes.The latter promotes tumor invasion and metastasis,angiogenesis,lymphangiogenesis,immune suppression,and reactivation of dormant disseminated tumor cells(DTCs),thereby facilitating tumor metastasis.In recent years,traditional Chinese medicine(TCM)has shown significant efficacy in inhibiting tumor metastasis and has been extensively validated.It exerts anti-tumor effects by reducing the recruitment of TAMs,inhibiting M2-like polarization,and modulating cytokines and proteins in the TME.This paper reviews the relationship between TAMs and lung cancer metastasis,elucidates the targets and mechanisms of TCM in regulating TAMs to prevent and treat lung cancer metastasis,aiming to pro-vide insights into lung cancer prevention and treatment.
