Relationship between GTSE1 and Cell Cycle and Potential Regulatory Mechanisms in Lung Cancer Cells
10.3779/j.issn.1009-3419.2024.106.13
- VernacularTitle:肺癌细胞中GTSE1与细胞周期的关系及潜在调控机制
- Author:
WANG CHUANLIN
1
;
XU JIALI
;
LIU MINGZHU
;
LIU JIAYU
;
HUANG YUNCHAO
;
ZHOU LAN
Author Information
1. 650118 昆明,昆明医科大学第三附属医院,云南省肿瘤医院临床营养科
- Keywords:
Lung neoplasms;
Cell cycle;
GTSE1;
Cell cycle regulator
- From:
Chinese Journal of Lung Cancer
2024;27(6):451-458
- CountryChina
- Language:Chinese
-
Abstract:
The regulation of the cell cycle is essential for maintaining normal cellular function,especially in the development of diseases such as lung cancer.The cell cycle consists of four major phases(G1,S,G2 and M phases),which are characterized by a series of precise molecular events to ensure proper cell proliferation and division.In lung cancer cells,cell cycle dysregulation can lead to disordered proliferation and increased invasiveness of cancer cells.G2 and S-phase expressed 1(GTSE1)is a regulatory protein found in the cytoplasm of the cell,which plays a key role in the cell cycle distribution of a wide range of cancer cells and is involved in life processes such as cell proliferation and apoptosis.GTSE1 affects cell cycle progres-sion by interacting with cyclin-dependent kinase inhibitor 1A(p21)and maintaining the stability of p21,which in turn inhibits the activity of cyclin-dependent kinase 1/2(CDK1/2).In addition,GTSE1 is also involved in the regulation of tumor protein 53(p53)signaling pathway.With the assistance of mouse double minute 2 homolog(MDM2),GTSE1 is able to transport p53 from the nucleus to the cytoplasm and promote its ubiquitination and degradation,thus affecting cell cycle and cell death-related signaling pathways.This paper reviews the expression of GTSE1 in lung cancer cells and its effects on lung cancer,as well as its potential mechanisms involved in cell cycle regulation.
