Differences of gap junctional communication among fibroblasts derived from pathological scars and normal skin
10.3760/j.issn:1009-4598.2001.02.010
- VernacularTitle:病理性瘢痕和正常皮肤成纤维细胞缝隙连接介导的细胞间通讯
- Author:
Feng LU
1
;
Jianhua GAO
;
Xiaojian LI
Author Information
1. Nanfang Hospital of the First Military Medical University
- From:
Chinese Journal of Plastic Surgery
2001;17(2):96-98
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the differences of the gap junctional communication among fibroblasts derived from pathological scars and normal skin. Methods Samples of hypertrophic scars, keloid and normal skin six, two of each, were collected. The means of cell culture was used to investigate gap junctional communication of the fibroblasts derived from these samples by adherent cell analysis and sorting interactive laser cytometer(ACAS 570). Results Fibroblasts derived from normal skin showed normal gap junction; gap junctional communication was restrained in fibroblasts derived from hypertrophic scars and the intercellular communication was completely obstructed in fibroblasts derived from keloids. Conclusion The obstruction of intercellular communication may play an important role in the pathogenesis of excessive and invasive growth of fibroblasts derived from keloid.
