Tumor-associated Macrophage:Emerging Targets for Modulating the Tumor Microenvironment
10.3779/j.issn.1009-3419.2024.102.13
- VernacularTitle:肿瘤相关巨噬细胞:调节肿瘤微环境的新靶点
- Author:
ZHOU YINXUE
1
;
REN DUNQIANG
;
BI HUANHUAN
;
YI BINGQIAN
;
ZHANG CAI
;
WANG HONGMEI
;
SUN JIAXING
Author Information
1. 266000 青岛,青岛大学附属医院呼吸与危重症医学科
- Keywords:
Tumor-associated macrophage;
Polarization;
Anti-angiogenic therapy;
Lung neoplasms
- From:
Chinese Journal of Lung Cancer
2024;27(3):231-240
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-associated macrophage(TAM)play a crucial role in the immune microenvironment of lung can-cer.Through changes in their phenotype and phagocytic functions,TAM contribute to the initiation and progression of lung cancer.By promoting the formation of an immune-suppressive microenvironment and accelerating the growth of abnormal tumor vasculature,TAM facilitate the invasion and metastasis of lung cancer.Macrophages can polarize into different subtypes with distinct functions and characteristics in response to various stimuli,categorized as anti-tumor M1 and pro-tumor M2 types.In tumor tissues,TAM typically polarize into the alternatively activated M2 phenotype,exhibiting inhibitory effects on tumor immunity.This article reviews the role of anti-angiogenic drugs in modulating TAM phenotypes,highlighting their po-tential to reprogram M2-type TAM into an anti-tumor M1 phenotype.Additionally,the functional alterations of TAM play a significant role in anti-angiogenic therapy and immunotherapy strategies.In summary,the regulation of TAM polarization and function opens up new avenues for lung cancer treatment and may serve as a novel target for modulating the immune microen-vironment of tumors.
