Research Progress on Tumor Metabolic Biomarkers in Liquid Biopsy of Lung Cancer
10.3779/j.issn.1009-3419.2023.106.29
- VernacularTitle:肿瘤代谢标志物在肺癌液体活检中的研究进展
- Author:
ZOU SHISHI
1
;
LI NING
;
ZHANG TIANYU
;
GENG QING
Author Information
1. 430060 武汉,武汉大学人民医院胸外科
- Keywords:
Lung neoplasms;
Metabolic biomarker;
Liquid biopsy;
Metabolomics
- From:
Chinese Journal of Lung Cancer
2024;27(2):126-132
- CountryChina
- Language:Chinese
-
Abstract:
Liquid biopsy is gradually being applied in the clinical diagnosis and treatment of lung cancer.At pres-ent,with the development of metabolomics,more and more metabolic biomarkers are considered as potential sensitive mark-ers reflecting the occurrence and development of tumors.This article summarizes the changes in the main metabolic pathways of lung cancer,including glucose metabolism,amino acid metabolism,lipid metabolism,sphingolipid metabolism,glycero-phospholipid metabolism,and purine metabolism.Meanwhile,this article reviews the role of metabolic biomarkers in the early diagnosis of lung cancer,predicting disease progression,and evaluating the efficacy of chemotherapy and immunotherapy,aim-ing to provide effective biomarkers for tumor diagnosis and treatment.
