Research progress of role and mechanism of ferroptosis in acute kidney injury

VernacularTitle:铁死亡在急性肾损伤中作用及机制的研究进展
Author: Jian WANG ^{1
,

2} ; Wei JI ; Bingyu REN ; Zhongbo LI ; Qian HE
Author Information

1. 长春理工大学生命科学技术学院,吉林长春,130000
2. 深圳职业技术大学食品药品学院,广东深圳,518000
Keywords: acute kidney injury; ferroptosis; lipid peroxidation; glutathione peroxidase 4
From: Journal of Clinical Medicine in Practice 2024;28(18):129-134
CountryChina
Language:Chinese
Abstract: Ferroptosis is a novel strategy for regulating cell death,and its occurrence is closely related to intracellular iron metabolism,lipid metabolism,amino acid metabolism,and various signa-ling pathways.Ferroptosis plays a pivotal role in the pathogenesis of acute kidney injury(AKI).Fer-roptosis may serve as an important target for the treatment of AKI caused by various reasons such as ischemia-reperfusion injury,nephrotoxic drugs,rhabdomyolysis syndrome,sepsis,and so on.This paper reviewed the regulatory mechanisms of ferroptosis and its research progress in AKI.