Mechanism and Prospect of Radiotherapy Combined with Apotatinib in the Treatment of Non-small Cell Lung Cancer
10.3779/j.issn.1009-3419.2017.12.09
- VernacularTitle:放疗联合阿帕替尼治疗非小细胞肺癌的机制及研究前景
- Author:
LIU GUOHUI
1
;
WANG CHUNBO
;
E MINGYAN
Author Information
1. 哈尔滨医科大学附属肿瘤医院放疗科
- Keywords:
Radiotherapy;
Apatinib;
Lung neoplasms;
Tumor microenvironment
- From:
Chinese Journal of Lung Cancer
2017;20(12):847-851
- CountryChina
- Language:Chinese
-
Abstract:
Non-small cell lung cancer is one of the most commom malignant tumor being harmful to people's life and health.Most of the patients have developed to the last stage which not suitable for surgical indications,so radiation and chemotherapy is the main treatment strategy.In recent years,with the theory of anti-angiogenesis therapy for malignant tumors,apatinib as a promising novel medicine to treat malignant tumors,represents synergistic antitumor effects in combination with radiotherapy.The underlying mechanisms may include make blood vessel normalization,alleviating inner hypoxia,and angiogenic factors regulation.Apatinib in combination with radiotherapy may become a new and effective treatment strategy of non-small cell lung cancer.
