Prognostic Analysis of Patients with Advanced Non-small Cell Lung Cancer in Different Genotypes
10.3779/j.issn.1009-3419.2017.11.04
- VernacularTitle:不同基因分型晚期非小细胞肺癌患者的预后分析
- Author:
LIU PING
1
;
WU YUHUA
;
ZHOU LIJUAN
;
QIN NA
;
ZHANG QUAN
;
ZHANG HUI
;
LI XI
;
ZHANG XINYONG
;
LV JIALIN
;
YANG XINJIE
;
WANG JINGHUI
;
ZHANG SHUCAI
Author Information
1. 101149 北京,首都医科大学附属北京胸科医院,北京市结核病胸部肿瘤研究所肿瘤内科
- Keywords:
Lung neoplasms;
Epidermal growth factor receptor;
Anaplastic lymphoma kinase;
Prognosis
- From:
Chinese Journal of Lung Cancer
2017;20(11):741-750
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective Non-small cell lung cancer (NSCLC) has been transformed from the treatment according to histological type to genotype treatment model. The epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) genes are the most important drivers in lung cancer. The aim of this study is to explore the clinical characteristics and prognostic factors of patients with advanced NSCLC with different genotypes. Methods We retrospectively reviewed the clinical data of 553 advanced NSCLC patients with EGFR mutations and ALK positive who were hospitalized in the Beijing Chest Hospital from July 2004 to December 2015, and the independent prognostic factors of pa-tients were analyzed by Cox proportional hazards regression model. Results The clinical data of 553 patients (227 with EGFR mutations, 58 with ALK positive, 2 with EGFR and ALK co-mutation and 266 with wild-type) with advanced NSCLC were enrolled in this study. The median survival time of 227 patients with EGFR mutations was 28.7 mo (95%CI: 22.160-35.240), and the performance status (PS) score (0-1) (HR=4.451; 95%CI: 2.112-9.382; P<0.001) and EGFR-tyrosine kinase inhibitors(TKIs) targeted therapy (HR=2.785; 95%CI: 1.871-4.145; P<0.001) were the independent prognostic factors for the survival of patients harboring EGFR mutations. The median survival time of 58 patients with ALK positive was 15.5 mo (95%CI:10.991-20.009), and treatment with crizotinib (P=0.022) was the independent influence factor for the survival of ALK positive patients. The median survival time of 266 patients with wild-type was 12.1 mo (95%CI: 10.660-13.540), and the PS score (0-1) (HR=2.313; 95%CI: 1.380-3.877; P=0.001) and treatment with chemotherapy (HR=1.911; 95%CI: 1.396-2.616; P<0.001) were the independent prognostic factors for the survival of wild-type patients. Conclusion The prognosis of patients with advanced NSCLC is associated with genetic mutation, and targeted therapy has a improvement on survival for patients with EGFR mutations or ALK rearrangement.
