Advances in Patient Derived Tumor Xenograft (PDTX) Model from Lung Cancer
10.3779/j.issn.1009-3419.2017.10.09
- VernacularTitle:肺癌PDTX模型的研究进展
- Author:
QIN BAODONG
1
;
JIAO XIAODONG
;
YUAN LINGYAN
;
LIU KE
;
ZANG YUANSHENG
Author Information
1. 上海长征医院肿瘤科
- Keywords:
Lung neoplasms;
Patient derived tumor xenograft;
Precision therapy
- From:
Chinese Journal of Lung Cancer
2017;20(10):715-719
- CountryChina
- Language:Chinese
-
Abstract:
With the development of tumor molecular biology and genomics, it has been recognized that there are great heterogeneity in the biological characteristics, molecular typing and reactivity of the same tumor species among different individuals. In order to achieve true tumor individualized and precise therapy, a new concept of human tumor tissue xenograftmodel (patient derived tumor xenograft, PDTX) is proposed. The previous study has revealed that PDTX model can truly reflect the biological characteristics of tumor tissue and drug efficacy. And PDTX model could be used to select individual che-motherapy regime, evaluate drug resistance and explore efficacy and safety of new drug. PDTX model has been used in clinical practice of several type of cancer including lung cancer. In this paper, the current research progress of lung cancer PDTX is reviewed.
