Reference Data of the Main Physiological Parameters in Control Sprague-Dawley Rats from Pre-clinical Toxicity Studies.
10.5625/lar.2010.26.2.153
- Author:
Zhong Ze HAN
1
;
Hong De XU
;
Kwang Ho KIM
;
Tae Hwan AHN
;
Jin Sook BAE
;
Ji Young LEE
;
Ki Hyun GIL
;
Joo Young LEE
;
Su Jung WOO
;
Hyun Jung YOO
;
Hyun Kul LEE
;
Kap Ho KIM
;
Chan Koo PARK
;
Hu Song ZHANG
;
Si Whan SONG
Author Information
1. Preclinical Research Center, ChemOn Inc., Yongin, Korea. swansong@chemon.co.kr
- Publication Type:Original Article
- Keywords:
Hematology;
reference data;
Sprague-Dawley rat;
pre-clinical toxicity studies
- MeSH:
Biochemistry;
Body Weight;
Hematology;
Organ Size;
Rats, Sprague-Dawley;
Urinalysis;
Water
- From:Laboratory Animal Research
2010;26(2):153-164
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The purpose of this paper is to provide reference data related to the body weight, food & water consumptions, urinalysis, hematology and serum biochemistry parameters and absolute & relative organ weights obtained from control Sprague-Dawley rats, used in the 4-week and 13-week repeated-dose toxicity studies conducted in our laboratory between 2005 and 2008. The mean, standard deviation, minimum and maximum range values for hematology and serum biochemistry parameters, data of absolute & relative organ weights, and the difference between sexes and study duration of week 4 versus 13 week are presented. The studies were conducted according to "the standards of Toxicity Study for Medicinal Products" (2005) and The KFDA Notification No. 2000-63 'Good Laboratory Practice (GLP)' (2000) issued by KFDA. These data could be used as reference material of Sprague-Dawley rats by conducting the studies to evaluate the toxicological profile of pre-clinical toxicity studies.
