Progress of Epigenetic Methylation in Lung Cancer Research
10.3779/j.issn.1009-3419.2017.09.08
- VernacularTitle:甲基化在肺癌研究领域的相关进展
- Author:
ZHANG SHAOWEI
1
;
XUE ZHIQIANG
Author Information
1. 中国人民解放军总医院胸外科一病区
- Keywords:
Lung neoplasms;
DNA methylation;
Methylation of Histone code;
Early detection of cancer;
Epigenetic agents;
Precision medicine
- From:
Chinese Journal of Lung Cancer
2017;20(9):635-640
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is becoming an increasing threat to Chinese residents and its incidence continues to rise while the treatment effect is far from satisfactory.Hence,it is essential to improve the level of early diagnosis,treatment,prognosis in lung cancer.An epigenetic trait is a stably heritable phenotype resulting from changes in a chromosome without alterations in the DNA sequence.The epigenetic studies,such as DNA methylation and histone methylation,are progressing rapidly in oncology research.A comprehensive understanding of its development status and existing problems is of great significance for the future research and the implementation of precision medicine.Herein,we aim to outline the progress ofDNA methylation and histone methylation modification in lung cancer and make a prospect for the future research.
