Research progress on the role of long non-coding RNA in regulating cancer radiosensitivity
- VernacularTitle:长链非编码RNA在调控癌症放疗敏感性中的研究进展
- Author:
Guanghao ZHU
1
;
Minhui ZHU
;
Hongliang ZHENG
Author Information
- Keywords: long non-coding RNA; cancer; radiotherapy; DNA repair; epithelial-mesenchy-mal transition; radiosensitivity
- From: Journal of Clinical Medicine in Practice 2024;28(16):142-148
- CountryChina
- Language:Chinese
- Abstract: The regulatory role of long non-coding RNA(lncRNA)in cancer radiosensitivity has obtained increasing attention.Radiotherapy is one of the primary treatment methods for cancer,yet some patients experience disease progression or recurrence due to radioresistance.Exploring the regu-latory mechanisms of radiosensitivity during cancer radiotherapy and identifying new molecular thera-peutic targets are crucial for enhancing the efficacy of cancer radiotherapy.LncRNA can participate in the response of cancer to radiotherapy and regulate cancer radiosensitivity through various pathways,including modulation of the DNA damage response,apoptosis,cancer stem cells,and epithelial-mesen-chymal transition(EMT).This study discussed the research progress on the mechanisms of lncRNA in the field of cancer radiotherapy,highlighting their important roles in enhancing tumor radiosensitivity.
