Expression of Serum LncRNA HOTAIR in Non-small Cell Lung Cancer and Its Clinical Significance

VernacularTitle:非小细胞肺癌血清中lncRNA HOTAIR的表达及临床意义
Author: TAN NAN ¹ ; LI LIHONG ; BAI LU ; ZHAO KUN
Author Information

1. 西安市第一医院干部病房科
Keywords: Lung neoplasms; Long noncoding RNA; HOX transcript antisense RNA; Clinical pathology
From: Chinese Journal of Lung Cancer 2017;20(6):402-406
CountryChina
Language:Chinese
Abstract: Background and objective The expression of long noncoding RNA HOX antisense RNA (HO-TAIR) is abnormal in a variety of tumors. The aim of this study is to explore the serum levels and clinical significance of HOTAIR in patients with non-small cell lung cancer (NSCLC). Methods The serum levels of HOTAIR were detected by real-time quantitative polymerase chain reaction (PCR) in 64 NSCLC patients and 64 normal controls. The rela-tionships between the serum levels of HOTAIR and clinical pathological parameters were analyzed. Results Compared with normal controls, the serum levels of HOTAIR in patients with NSCLC increased significantly (P<0.01). The serum levels of HOTAIR were correlated with tumor size, tumor-node-metastasis (TNM) stage and lymph node me-tastasis (P<0.05), but not with age, gender, smoking, differentiation and histology (P>0.05). Conclusion The serum levels of HOTAIR in patients with NSCLC are significantly higher, and HOTAIR may be involved in the pathogenesis of NSCLC.