Overexpression of OLC1 in Lung Squamous Cell Carcinoma Tissues is Associated with Poor Prognosis of Patients
10.3779/j.issn.1009-3419.2017.05.08
- VernacularTitle:OLC1在肺鳞癌组织中的过表达与患者的不良预后相关
- Author:
ZHANG KUNPENG
1
;
ZHAO GEFEI
;
XIAO TING
;
LI PING
;
SONG JIE
;
GAO YANNING
;
SUN KELIN
Author Information
1. 100021 北京,国家癌症中心/中国医学科学院北京协和医学院肿瘤医院,分子肿瘤学国家重点实验室癌发生与预防分子机理北京市重点实验室
- Keywords:
OLC1;
Immunohistochemical staining;
Lung squamous cell carcinoma;
Prognosis
- From:
Chinese Journal of Lung Cancer
2017;20(5):346-351
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective OLC1 (overexpressed in lung cancer 1), screened out and cloned in our previous research, is a new gene associated with lung cancer. It is highly expressed in lung cancer and many other malignant tu-mors, and is associated with poor prognosis of esophageal squamous cell carcinoma, ovarian cancer, breast cancer and colorec-tal cancer. The aim of this research was to detect the expression level of OLC1 in the tumor tissues of lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) and explore its relationship with the prognosis of lung cancer patients. Methods Lung cancer tissues of 108 SCC and 90 ADC was dealed with immunohistochemical staining to detect the expression level of OLC1. The relationship between the expression level of OLC1 and clinical parameters and prognosis was analyzed. Results The rate of high expression of OLC1 staining in ADC was significantly higher than that in SCC (87.5% vs 55.3%, P<0.001). The overexpression of OLC1 in tumor tissues did not have a significant relationship with the prognosis of patients with ADC, but it was related with a poor prognosis of SCC patients as the univariate analysis showed. However the multivariate regression analysis showed that correlation between the overexpression of OLC1 and poor prognosis of SCC patients did not have a statis-tical significance (P=0.05). Conclusion The expression of OLC1 in ADC might be higher than that in SCC. A higher score of OLC1 staining in tumor tissue was associated with a poorer prognosis of patients with SCC, but could not be an independent predictor for a shorter overall survival in patients with SCC.
