Progress of c-MET Signaling Pathway and TKIs in Non-small Cell Lung Cancer
10.3779/j.issn.1009-3419.2017.04.10
- VernacularTitle:c-MET通路和抑制剂在非小细胞肺癌中的研究进展
- Author:
YU XIAOQING
1
Author Information
1. 浙江中医药大学
- Keywords:
Lung neoplasms;
c-MET;
Amplification;
Crizotinib
- From:
Chinese Journal of Lung Cancer
2017;20(4):287-292
- CountryChina
- Language:Chinese
-
Abstract:
c-MET is considered a promising oncogenic driver in non-small cell lung cancer (NSCLC) after the discovery of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK).MET activation including gene mutation,amplification and protein overexpression,all of these are potential therapeutic targets and are associated with poor prognosis.Clinical evidence suggests a role for MET activation as both a primary oncogenic driver in subsets of lung cancer,and as a secondary driver of acquired resistance to EGFR-tyrosine kinase inhibitor (TKI).This review focuses on the MET activation in NSCLC and the latest trials of its treatment.
