Preoperatiove Airway Bacterial Colonization: the Missing Link between Non-small Cell Lung Cancer Following Lobectomy and Postoperative Pneumonia?
10.3779/j.issn.1009-3419.2017.04.03
- VernacularTitle:肺癌肺叶切除患者术前存在气道定植菌与术后肺炎的发生有相关性吗?
- Author:
GAO KE
1
,
2
;
LAI YUTIAN
;
HUANG JIAN
;
WANG YIFAN
;
WANG XIAOWEI
;
CHE GUOWEI
Author Information
1. 610017成都,成都市第二人民医院胸心外科
2. 610041成都,四川大学华西医院胸外科
- Keywords:
Lung neoplasms;
Pathogenic airway bacterial colonization;
Surfactant protein D (SP-D);
Postoperative pneumonia (POP)
- From:
Chinese Journal of Lung Cancer
2017;20(4):239-247
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective Surgical procedure is the main method of treating lung cancer.Meanwhile,postoperative pneumonia (POP) is the major cause of perioperative mortality in lung cancer surgery.The preoperative pathogenic airway bacterial colonization is an independent risk factor causing postoperative pulmonary complications (PPC).This cross-sectional study aimed to explore the relationship between preoperative pathogenic airway bacterial colonization and POP in lung cancer and to identify the high-risk factors of preoperative pathogenic airway bacterial colonization.Methods A total of 125 patients with non-small cell lung cancer (NSCLC) underwent thoracic surgery in six hospitals of Chengdu between May 2015 and January 2016.Preoperative pathogenic airway bacterial colonization was detected in all patients via fiber bronchoscopy.Patients' PPC,high-risk factors,clinical characteristics,and the serum surfactant protein D (SP-D) level were also analyzed.Results The incidence of preoperative pathogenic airway bacterial colonization among NSCLC patients was 15.2％ (19/125).Up to 22 strains were identified in the colonization positive group,with Gram-negative bacteria being dominant (86.36％,19/22).High-risk factors of pathogenic airway bacterial colonization were age (≥75 yr) and smoking index (≥≥400 cigarettes/year).PPC incidence was significantly higher in the colonization-positive group (42.11％,8/19) than that in the colonization-negative group (16.04％,17/106)(P=0.021).POP incidence was significantly higher in the colonization-positive group (26.32％,5/19) than that in the colonization-negative group (6.60％,7/106)(P=0.019).The serum SP-D level of patients in the colonization-positive group was remarkably higher than that in the colonization-negative group [(31.25±6.09)vs (28.17±5.23)] (P=0.023).The incidence of preoperative pathogenic airway bacterial colonization among NSCLC patients with POP was 41.67％ (5/12).Ihis value was 3.4 times higher than that among the patients without POP (OR=3.363,95％CI:1.467-7.711).Conclusion An intimate correlation was observed between POP and pathogenic airway bacterial colonization in lung cancer.The high-risk factors of pathogenic airway bacterial colonization were age and smoking index.
