Correlation of serum asprosin with atrial fibrillation
- VernacularTitle:血清白脂素与心房颤动的相关性研究
- Author:
Hao YANG
1
;
Xue YU
;
Han YAO
;
Runze CHI
;
Xiaoli SHAN
;
Bingong LI
Author Information
- Keywords: asprosin; atrial fibrillation; adipokine; inflammatory response; left atrial diameter
- From: Journal of Clinical Medicine in Practice 2024;28(15):36-42
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the correlation between serum asprosin level and atrial fibrillation.Methods A total of 85 hospitalized patients with atrial fibrillation in the Department of Cardiology of Qingdao Municipal Hospital from October 2021 to October 2023 were selected as atrial fibrillation group,and 86 hospitalized patients with normal sinus rhythm in the same period were selected as non-atrial fibrillation group.Clinical materials and serum asprosin level of patients were collected and compared.Logistic regression analysis was performed to establish a linear stepwise regression model based on potential confounding factors for exploration in the independent risk factors for atrial fibrillation.Receiver operating characteristic(ROC)curve was used to evaluate the diagnos-tic value of asprosin for atrial fibrillation.Results Serum asprosin level in the atrial fibrillation group,was significantly higher than that in the non-atrial fibrillation group(P＜0.001).The linear stepwise regression model showed that asprosin was an independent risk factor for atrial fibrillation(OR=1.020,95％CI,1.005 to 1.036,P=0.01).The ROC curve showed that the area under the curve of serum asprosin in predicting atrial fibrillation was 0.745(95％CI,0.670 to 0.819).Conclusions Serum asprosin level is significantly elevated in patients with atrial fibrillation,and as-prosin is an independent risk factor for atrial fibrillation.Serum asprosin level has good diagnostic val-ue for atrial fibrillation.
