Relationship of C1QA level and therapeutic effect and prognosis of DLBCL patients treated with R-CHOP
10.3760/cma.j.cn112152-20200307-00179
- VernacularTitle:C1QA水平与R-CHOP方案治疗弥漫大B细胞淋巴瘤患者疗效和预后的关系
- Author:
Yanrong WANG
1
;
Jianliang YANG
;
Yan QIN
;
Shengyu ZHOU
;
Peng LIU
;
Xiaohui HE
;
Shiyu JIANG
;
Fengyi ZHAO
;
Qiaofeng ZHONG
;
Yu ZHOU
;
Yang LI
;
Meng XU
;
Xiaobo YU
;
Xiaohong HAN
;
Yuankai SHI
Author Information
1. 国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院内科 抗肿瘤分子靶向药物临床研究北京市重点实验室 100021
- Keywords:
Diffuse large B-cell lymphoma;
Complement;
C1Q;
C1QA;
Rituximab
- From:
Chinese Journal of Oncology
2021;43(12):1310-1315
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between plasma levels of complements before treatment and the clinicopathological feathers and prognoses of diffuse large B-cell lymphoma (DLBCL) patients treated with Rituximab (R)-CHOP or R-CHOP-like therapy.Methods:The clinicopathological data of 105 DLBCL patients treated in cancer Hospital of Chinese Academy of Medical Sciences from 2010 to 2016 were collected. The plasma samples from 105 DLBCL patients treated with R-CHOP or R-CHOP-like therapy and 80 healthy controls were used to detect 34 complement levels before treatment by utilizing antibody microarray. The relationship between plasma levels of complements and the clinicopathological feathers and prognosis of DLBCL patients were analyzed.Results:The signal values of C1QA and CR1L in patients with international prognostic index (IPI) scores of 3-5 were 1 261.43±138.9 and 2 214.69±98.58, respectively, higher than 950.79±80.19 and 984.67±121.79 in patients with IPI scores of 0~2 (both P<0.05). The levels of C1QA and CR1L in the non-complete response (CR) group were 1 165.43±98.56 and 2 263.13±145.63, respectively, higher than 914.70±100.77 and 1 821.34±84.68 in the CR group (both P<0.05). Cox regression analysis showed that elevated C1QA signal value was associated with poor progression-free survival (PFS) and poor overall survival (OS) (PFS: HR=2.063, 95% CI: 1.220-3.489, P=0.007; OS: HR=2.23, 95% CI: 1.036~4.798, P=0.040). After IPI correction by Cox multivariate model, the elevated C1QA signal value was still correlated with poor PFS ( HR=1.765, 95% CI 1.034~3.013, P=0.037). Conclusions:The baseline plasma levels of C1QA and CR1L are correlated with IPI scores and therapeutic effects of DLBCL patients treated with R-CHOP. The baseline plasma level of C1QA has a certain predictive value for the prognostic evaluation of DLBCL.
