Advances in the Research of the Regulation of Chinese Traditional Medicine Monomer and Its Derivatives on Autophagy in Non-small Cell Lung Cancer
10.3779/j.issn.1009-3419.2017.03.10
- VernacularTitle:天然中药单体及衍生物调控非小细胞肺癌自噬的研究新进展
- Author:
XIANG MEIYI
1
;
LI RUILEI
;
ZHANG ZHIWEI
;
SONG XIN
Author Information
1. 650500 昆明,云南省昆明医科大学第三附属医院,云南省肿瘤医院生物治疗中心
- Keywords:
Lung neoplasms;
Chinese herbal or plant extracts;
Autophagy;
Drug resistance
- From:
Chinese Journal of Lung Cancer
2017;20(3):205-212
- CountryChina
- Language:Chinese
-
Abstract:
The high morbidity and mortality of non-small cell lung cancer (NSCLC) did influence the quality of life of tumor patients world-wide. There is an urgent need to develop new therapies that have high anti-tumor activity and low toxicity side effects. It is widely accepted that autophagy can play diverse roles in carcinogenesis, such as induces pro-death of lung cancer cells or helps the escape from cell death, making it become a proper anticancer target. It's believed that various monomers of Chinese traditional medicine closely correlates to anti-NSCLC activities, and that even could affect the acquired multiple drug resistance (MDR). Furthermore, autophagy might be the underling mechanisms which could play a role as the candidate targets of natural active compounds. Recent studies of terpenoids, alkaloid, dietary polyphenols, saponins and other active ingredients that extracted from a large variety of herbs suggest that different monomer compounds could either regulate the activity of pro-death autophagy or influence the level of protective autophagy of NSCLC cells, thus changing their drug sensitivity and cell viability. This paper aims to give a systemic description of the latest advances about natural compounds and their derivatives that involved in tumorigenesis of NSCLC via inducing the autophagy.
