Advances in Classification and Research Methods of Lung Epithelial Stem and Progenitor Cells
10.3779/j.issn.1009-3419.2017.02.08
- VernacularTitle:肺上皮干/祖细胞种类和研究方法进展
- Author:
DENG MINHUA
1
,
2
;
LI JINHUA
;
GAN YE
;
CHEN PING
Author Information
1. 100088 北京,中国人民解放军火箭军总医院呼吸内科
2. 410011长沙,中南大学湘雅二医院呼吸内科
- Keywords:
Lung epithelial stem cells;
Lung epithelial progenitor cells;
Phenotype;
Lung cancer stem cells
- From:
Chinese Journal of Lung Cancer
2017;20(2):130-137
- CountryChina
- Language:Chinese
-
Abstract:
Isolation and characterization of lung epithelial stem and progenitor cells and understanding of their specific role in lung physiopathology are critical for preventing and controlling lung diseases including lung cancer. In this re-view, we summarized recent advances in classification and research methods of lung epithelial stem and progenitor cells. Lung epithelial stem and progenitor cells were region-specific, which primarily included basal cells and duct cells in proximal airway, Clara cells, variant Clara cells, bronchioalveolar stem cells and induced krt5+ cells in bronchioles, type Ⅱ alveolar cells and type Ⅱ alveolar progenitor cells in alveoli. The research methods of lung epithelial stem and progenitor cells were mainly focused on lung injury models, lineage-tracing experiments, three dimensional culture, transplantation, chronic labeled cells and single-cell transcriptome analysis. Lastly, the potential relationship between lung epithelial stem and progenitor cells and lung cancer as well as lung cancer stem cell-targeted drug development were briefly reviewed.
