Expression and Clinical Signiifcance of PD-1 and PD-L1 in Pulmonary Carcinoids
10.3779/j.issn.1009-3419.2016.12.07
- VernacularTitle:PD-1和PD-L1在肺类癌中的表达情况和其临床意义
- Author:
LI MINGBIAO
1
;
XU SONG
;
FAN HAIYANG
;
ZHANG HONGYI
;
LI YING
;
LI YONGWEN
;
LIU MINGHUI
;
LIU HONGYU
;
CHEN JUN
Author Information
1. 300052天津，天津医科大学总医院肺部肿瘤外科，天津市肺癌研究所，天津市肺癌转移与肿瘤微环境实验室
- Keywords:
Lung neoplasms;
Pulmonary carcinoid;
Programmed death-1 (PD-1);
Programmed death ligand-1
- From:
Chinese Journal of Lung Cancer
2016;19(12):847-853
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective The incidence of pulmonary carcinoid (PC) is very rare in primary lung malignant tumors, and the prognosis of this disease is closely associated with its pathological features. In this study, the expres-sions of programmed death 1 (PD-1) and programmed death ligand-1 (PD-L1) in lung carcinoid cells were detected, and the correlation between the expression and corresponding clinical physiological and pathologic features was further analyzed. Methods The expressions of PD-1 and PD-L1 in 20 cases of PC paraffn-embedded tissue specimens were detected through immunohistochemistry. hTe H-score of immunohis to chemical staining (range, 0-300) was employed to evaluate the expres-sion of PD-1 and PD-L1 in the tumor tissues.Results In the 20 cases of patients with PC, 40% (8/20) showed positive expres-sions of PD-1, and 45% (9/20) showed positive expressions of PD-L1. Signiifcantly higher expressions of PD-1 were observed in the smoking patients than in the nonsmoking patients (63.64%vs 11.11%,P<0.05). Furthermore, no signiifcant relationship was found between the expressions of PD-1 and PD-L1 and the clinical characteristics of the patients, such as age, gender, pathological type, clinical stage, and metastasis (P>0.05).Conclusion Approximately 40% of PC patients had positive expres-sions of PD-1or PD-L1. The positive expression rate of PD-1 in the smoking patients was signiifcantly higher than that in the nonsmoking patients. hTese results suggest that the expressions of PD-1 and PD-L1 may be associated with the occurrence and development of PC.(PD-L1)
