Correlation analysis of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio and central cervical lymph node metastasis of papillary thyroid microcarcinoma
10.3760/cma.j.cn112152-20200509-00434
- VernacularTitle:中性粒细胞淋巴细胞计数比值和血小板淋巴细胞计数比值与甲状腺微小乳头状癌中央区淋巴结转移的关系
- Author:
Chuangye SONG
1
;
Yanlin MENG
;
Bing LIU
;
Li YAN
;
Peizhong SHANG
;
Zhifang JIA
;
Yongbin JIANG
;
Fanyu MENG
Author Information
1. 解放军陆军第八十一集团军医院普通外科，张家口 075000
- Keywords:
Thyroid neoplasms;
Papillary thyroid microcarcinoma;
Neutrophil-to-lymphocyte ratio;
Platelet-to-lymphocyte ratio;
Central lymph node metastasis
- From:
Chinese Journal of Oncology
2021;43(9):944-948
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and central lymph node metastasis (CLNM) in patients with cN0 papillary thyroid microcarcinoma (PTMC).Methods:The clinicopathological data of PTMC patients confirmed by surgery and pathology in the 81 st Military Hospital of People′s Liberation Army from 2016 to 2019 were collected, and the relationship between preoperative NLR, PLR levels and postoperative PTMC CLNM were analyzed. Logistic regression analysis was used for multivariate analysis. Receiver operating characteristic (ROC) curve was used to determine the cutoff value of NLR and PLR. The interaction relative excess risk was used to analyze the relationship between NLR, PLR and CLNM. Results:Among 220 patients with cN0 stage PTMC, 92 were CLNM. The ROC curve showed that when the cutoff value of NLR was 2.5 and the cutoff value of PLR was 175, the highest Youden index was 0.318 and 0.264, respectively. NLR and PLR were both related to CLNM ( P<0.05). The tumor long diameter, multifocality, NLR≥2.5 and PLR≥175 were independent impact factors of CLNM ( P<0.05). The results of the interaction showed that the relative excess risk of the interaction was 5.531 (95% CI: 0.160, 10.901, P=0.016), the attribution ratio was 0.512 (95% CI: 0.230, 0.794, P=0.009), and the synergy index was 2.294 (95% CI: 1.492, 4.579, P=0.022), suggested that NLR and PLR had an interactive effect, and these two synergistically promoted CLNM. Conclusions:NLR and PLR are independent risk factors for cN0 stage PTMC CLNM. When NLR≥2.5 and PLR≥175, preventive central lymph node dissection should be routinely performed.
