Clinical Analysis of 58 Patients with Small Cell Lung Cancer Combined with Squamous Cell Cancer
10.3779/j.issn.1009-3419.2016.10.04
- VernacularTitle:58例小细胞癌与鳞癌复合型肺癌的临床分析
- Author:
LUO YANG
1
;
MEN YU
;
HUI ZHOUGUANG
;
LI JUNLING
;
HAO XUEZHI
;
XING PUYUAN
Author Information
1. 国家癌症中心/中国医学科学院北京协和医学院肿瘤医院内科
- Keywords:
Lung neosplasms;
Small cell carcinoma;
Squamous cell carcinoma;
Combined carcinoma
- From:
Chinese Journal of Lung Cancer
2016;19(10):659-664
- CountryChina
- Language:Chinese
-
Abstract:
Background and objectiveSmall cell lung cancer combined with squamous cell carcinoma are rare. hTe aim of this study was to analyze the clinicopathological characteristics and treatment, and explored the prognostic factors of this disease.MethodsBetween January 2004 and December 2012, 58 patients with cytopathologically conifrmed small cell lung cancers combined with squamous cell carcinoma were retrospectively analyzed.Kaplan-Meier methods were used to calculate the survival rate, andLog-rank test was used to examine differences between arms. hTeCox regression model was used to analyze the independent factors affecting the overall survival (OS).Results hTe OS of the 58 patients was 22.7 months with a range of 0.3 to 124.3 months. In univariate analysis, Karnofsky performance score before treatment, extensive disease, tumor stage were the considered prognostic factors affecting the OS rate (P<0.05).Cox multivariate analysis showed that only the tumor-node-metastasis (TNM) stage was the independent prognostic factor (P=0.019). hTe majority of the patients received multimodality therapy and chemotherapy was the main treatment. Distant metastasis was the main reasonfor the treatment failure.ConclusionCombined therapy with chemotherapy as the main treatment should be adopted in therapeutic regimen of the patients with small cell lung cancers combined with squamous cell carcinoma. TNM stage was the independent prognos-tic factor inlfuencing the OS.
