Clinicopathologic Features and Prognostic Implications in 72 Cases with Lung Adenosquamous Carcinoma

VernacularTitle:72例肺腺鳞癌临床病理特点和预后因素分析
Author: WU XI ¹ ; LI JUNLING ; CHEN SHULAN ; YU LEI ; YANG BOYAN
Author Information

1. 国家癌症中心/中国医学科学院北京协和医学院肿瘤医院综合科
Keywords: Lung neoplasms; Adenosquamous carcinoma; Clinicopathology; Prognosis
From: Chinese Journal of Lung Cancer 2016;19(10):653-658
CountryChina
Language:Chinese
Abstract: Background and objectiveAdenosquamous carcinoma (ASC) is a rare subtype of lung cancer, it is mixed glandular and squamous cell carcinoma with a more aggressive behavior and poor prognosis than the other histologic subtypes. hTe aim of the study was to explore the clinicopathological characteristics and prognostic factors of ASC.Methods A total of 72 patients were enrolled. We investigated clinicalpathological features and prognostic factors retrospectively.Results hTe overall 72 ASC patients’ median age was 34.7 months, 5-year survival rate was 14.9%. hTe inlfuence of tumor size, M stage, and N stage, gene mutation and surgery on the prognosis of patients show statistical signiifcance.Conclusion ASC is charac-terized by both histologic aggressiveness and adverse prognosis. We suggest the comprehensive therapy based on surgery, and given small molecule tyrosine kinase inhibitors (TKIs) treatment may prolong patients’ overall survival.