Interventional effect of repetitive transcranial magnetic stimulation on tardive dyskinesia in schizophrenic patients
- VernacularTitle:重复经颅磁刺激对精神分裂症患者迟发性运动障碍的干预效果
- Author:
Yali LIU
1
;
Kesong LI
;
Hongqiang JIN
;
Yue CUI
;
Xiaofang WANG
;
Ya LIU
;
Yu GAO
;
Yunzhao CHEN
Author Information
- Keywords: repetitive transcranial magnetic stimulation; tardive dyskinesia; schizophrenia; intervention mode; curative effect
- From: Journal of Clinical Medicine in Practice 2024;28(13):98-102,108
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the interventional effect of repetitive transcranial magnetic stimulation(rTMS)on tardive dyskinesia(TD)in schizophrenic patients.Methods A total of 105 schizophrenic patients were selected as subjects and randomly divided into 1 Hz treatment group,10 Hz treatment group and control group,with 35 patients in each group.All three groups received rTMS treatment for 12 weeks.The Abnormal Involuntary Movement Scale(AIMS),Scale for the As-sessment of Negative Symptoms(SANS),Positive and Negative Syndrome Scale(PANSS)and Treat-ment Emergent Symptom Scale(TESS)scores were compared among the three groups.Physiological indicators such as electrocardiogram,blood routine,blood biochemistry and hormone levels were mo-nitored.Results After treatment,the total AIMS scores in the 1 Hz and 10 Hz treatment groups were significantly lower than before treatment,and those in the 1 Hz and 10 Hz treatment groups were significantly lower than those in the control group(P＜0.05).The reduction rates of AIMS scores in the 1 Hz and 10 Hz treatment groups were 68.6％and 65.7％,respectively,which were significantly higher than the 22.9％in the control group(P＜0.05).After treatment,the total SANS and PANSS scores in the 1 Hz and 10 Hz treatment groups were significantly lower than before treatment,and those in the 1 Hz and 10 Hz treatment groups were significantly lower than those in the control group(P＜0.05).There was no statistically significant difference in the total AIMS score,efficacy and total PANSS score between the 1 Hz and 10 Hz treatment groups(P＞0.05).There were no significant differences in the total TESS scores and physiological indicators among the three groups before and after treatment(P＞0.05).Conclusion Both 1 Hz and 10 Hz rTMS can effectively improve TD in schizophrenic patients with good safety and have no significant side effects or physiological damage.
